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Ý nghĩa và kiểm tra định lượng 5 hạng mục viêm gan B?  

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08:08 30/08/2014

Viêm gan B là một loại bệnh truyền nhiễm có tính “cứng đầu”, thời gian điều trị dài, sau khi trải qua 1 thời gian điều trị có một bộ phận bệnh nhân có thể chữa khỏi hoàn .. [..]

Viêm gan B là một loại bệnh truyền nhiễm có tính “cứng đầu”, thời gian điều trị dài, sau khi trải qua 1 thời gian điều trị có một bộ phận bệnh nhân có thể chữa khỏi hoàn toàn. Sau đây là chỉ tiêu kiểm tra định lượng 5 hạng mục viêm gan B mà chúng ta nên tham khảo để theo dõi tiến triển của bệnh.


1. Kiểm tra định lượng HBsAg

  • Giá trị tham khảo: 0-0.05IU/mL
  • Ý nghĩa lâm sàng
  • Có thể làm chỉ tiêu tham khảo sự sao chéo virus viêm gan B ở người mang virus viêm gan B
  • Đánh giá hiệu quả điều trị Lamivudine
  • Kiếm tra sự sao chép virus viêm gan B ở bệnh nhân ứng dụng điều trị alpha-interferon
  • Xác định lượng sử dụng globulin miễn dịch ở bệnh nhân ghép gan

2. Kiểm tra định lượng Anti-HBs

  • Là kháng thể đặc trưng sản sinh trong cơ thể kích thích HbsAg, là 1 loại kháng thể có tính bảo vệ có thể trung hòa HBV
  • Hàm lượng Anti-HBs ở mức 0-10mIU/ml chứng tỏ không có tính bảo vệ, cần tiêm vaccine viêm gan B (3 mũi: phương án 0-1-6)
  • Hàm lượng Anti-Hbs 10-100mIU/ml, chứng tỏ rằng đã có tính bảo vệ, nhưng còn khá yếu, cần tiêm phòng nhắc lại viêm gan B (1 mũi)
  • Hàm lượng Anti-Hbs lớn hơn 100mIU/ml, chứng tỏ rằng tính bảo vệ đã rất mạnh, không cần tiêm phòng vaccine viêm gan B nữa.

3. HBeAg

HbeAg tăng cao chứng tỏ virus đang sao chép, có tính truyền nhiễm rất lớn.

4. Anti-HBe

HbeAg dương tính chứng tỏ sự sao chép virus viêm gan B giảm đi, tính truyền nhiễm yếu, nhưng vẫn có tính truyền nhiễm. Anti-Hbe không phải là kháng thể mang tính bảo vệ, là tiêu chí thời gian truyền nhiễm virus viêm gan B khá dài.

5. Anti-HBc

  • Sự cao thấp của nồng độ HbcAb có thể phản ánh trạng thái truyền nhiễm virus, nồng độ cao HbcAb chứng tỏ sự truyền nhiễm cấp tính viêm gan B, nồng độ thấp thường là thời kì phục hồi hoặc truyền nhiễm trước đây, có lợi cho sự phán đoán tính hoạt động và không hoạt động của viêm gan mãn tính, có thể dùng cho sự phân loại viêm gan B mãn tính.
  • Anti-HBc không phải là 1 loại kháng thể có 2 hình thức là IgG và IgM. IgM xuất hiện ở thời kì đầu mà IgG xuất hiện ở thời kì khôi phục, có thể duy trì nhiều nằm hoặc tồn tại suốt đời.

Chú ý: Trên đây là những thông tin  mà các bạn có thể tham khảo, để biết  thêm chi tiết và được hứơng dẫn cụ thể, hãy gọi đến tổng đài tư vấn 1900.6180 để  nhận được tư vấn trực tiếp từ các bác sĩ.


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